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From the Saint-Charles railway station, during the day, until about 9pm: take subway M2 towards Sainte-Marguerite Dromel; get off at the Rond-Point du Prado stop; take the B1 bus towards Campus de Luminy; get off at the Campus de Luminy stop, which is also the terminus and 3 minutes from CIRM on foot
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From the Saint-Charles railway station, at night, from about 9pm: take the 521 bus, towards Luminy PN des Calanques; get off at the Luminy PN des Calanques stop, which is also the terminus and 10 minutes from CIRM on foot
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From the airport, day or night, take the L91 bus, which goes directly to the Saint-Charles station; then, use one of the two options above
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more information on the CIRM website and on the Marseille public transport website.